Episode 17: Gabapentin Abuse

Episode 17: Gabapentin Abuse

Medication Minute, Psychopharmacology
On today's Medication Minute, we will be discussing gabapentin, including its pharmacology, use in management of psychiatric diagnoses, and it’s more recent growing potential for abuse. Gabapentin is a gamma-aminobutyric acid analog that is was approved for use as an antiepileptic in 1993 and for post-herpetic neuralgia in 2004, but is also used off label for alcohol withdrawal symptoms, diabetic neuropathy, fibromyalgia, restless legs syndrome, and other types of neuropathic pain. References Sadock, Benjamin James. Sadock, Virginia Alcott. Ruiz, Pedro. Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. Philadelphia: Lippincott Williams & Wilkins, 2015. Print. Smith, Rachel V., et al. “Gabapentin misuse, abuse, and diversion: a systematic review.” Addiction, vol. 111, no. 7, 2016, pp. 1160-1174., doi:10.1111/add.13324. Reccoppa, Lawrence, et al. “Gabapentin abuse in inmates with prior history of…
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Episode 15: α2-Adrenergic Receptor Agonists and Antagonists

Episode 15: α2-Adrenergic Receptor Agonists and Antagonists

Medication Minute, Psychopharmacology
Today’s episode is part of our medication minute series, and today we will be doing a brief review of alpha 2 adrenergic receptor agonists and antagonists, in the context of their psychiatric uses. This discussion will include pharmacodynamics properties, indications for use, side effects and dosing. We discuss specifically clonidine, guanfacine, prazosin, and yohimbine. References Sadock, Benjamin James. Sadock, Virginia Alcott. Ruiz, Pedro. Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. Philadelphia: Lippincott Williams & Wilkins, 2015. Print. “Prazosin: Drug Information.” com. Web. 27 May 2018. “Clonidine: Drug Information.” com. Web. 27 May 2018. Stein, Murray B, PhD. “Pharmacotherapy for posttraumatic stress disorder in adults.” com. 28 March 2018. Web. 27 May 2018. Sareen, Jitender MD. “Posttraumatic stress disorder in adults: Epidemiology, pathophysiology, clinical manifestations, course, assessment and diagnosis.”…
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Episode 9: Suvorexant

Episode 9: Suvorexant

Medication Minute, Psychopharmacology
Today’s episode is part of my Medication Minute series. As previously described, these shorter episodes feature information regarding a specific subset of psychiatric medication management. On today’s episode, I want to discuss a newer medication called suvorexant, or trade name Belsomra, an orexin antagonist that was FDA-approved for treatment of insomnia. References Bonnet, MH PhD, DL Arand PhD. “Treatment of insomnia in adults.” UpToDate, 10 August 2017. Web. 23 August 2017. Yang, Lily P.H. “Suvorexant: First Global Approval.” Drugs, vol. 74, no. 15, 2014, pp. 1817-1822., doi:10.1007/s40265-014-0294-5. “Suvorexant.” Wikipedia, Wikimedia Foundation, 9 Aug. 2017, en.wikipedia.org/wiki/Suvorexant. “Suvorexant: Drug Information.” UpToDate, 2017. Web. 23 August 2017. Vermeeren, Annemiek, et al. “On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 Mg: A Study in Non-Elderly Healthy Volunteers.” Sleep, vol. 38,…
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Episode 6: Antidepressant-Induced Sexual Dysfunction

Episode 6: Antidepressant-Induced Sexual Dysfunction

Medication Minute, Psychopharmacology
On today’s episode, we will be discussing treatment of antidepressant-induced sexual dysfunction. This is a topic that is incredibly important in terms of medication management in our patients and the side effects from some of those medications, and it is a topic that is often overlooked. It can be embarrassing and anxiety-provoking for medical students, residents, and even attending psychiatrists to ask these questions of our patients. However, it is a vital aspect of our assessment, and even more so when so many medications can cause such an undesirable side effect. First, we will discuss the evaluation of these side effects during psychiatric assessment, followed by a discussion of the management techniques for antidepressant-induced sexual dysfunction. References Sadock, Benjamin James. Sadock, Virginia Alcott. Ruiz, Pedro. Kaplan & Sadock's Synopsis of…
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