Episode 17: Gabapentin Abuse

On today’s Medication Minute, we will be discussing gabapentin, including its pharmacology, use in management of psychiatric diagnoses, and it’s more recent growing potential for abuse. Gabapentin is a gamma-aminobutyric acid analog that is was approved for use as an antiepileptic in 1993 and for post-herpetic neuralgia in 2004, but is also used off label for alcohol withdrawal symptoms, diabetic neuropathy, fibromyalgia, restless legs syndrome, and other types of neuropathic pain.

References

  1. Sadock, Benjamin James. Sadock, Virginia Alcott. Ruiz, Pedro. Kaplan & Sadock’s Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. Philadelphia: Lippincott Williams & Wilkins, 2015. Print.
  2. Smith, Rachel V., et al. “Gabapentin misuse, abuse, and diversion: a systematic review.” Addiction, vol. 111, no. 7, 2016, pp. 1160-1174., doi:10.1111/add.13324.
  3. Reccoppa, Lawrence, et al. “Gabapentin abuse in inmates with prior history of cocaine dependence.” American Journal on Addictions, vol. 13, no. 3, 2004, pp. 321-323., doi:10.1080/10550490490460300.
  4. “Gabapentin: Drug information.” com. Web. 18 October 2018.
  5. Peckham, Alyssa M. et al. “Prevalence of gabapentin abuse: comparison with agents with known abuse potential in a commercially insured US population.” Clinical Drug Investigation, 37, no. 8, 2018, pp. 763-773., doi:10/1007/s40261-017-0530-3. 20 October 2018.
  6. Berlin, Rachel K., et al. “Gabapentin Therapy in Psychiatric Disorders.” The Primary Care Companion For CNS Disorders, 2015, doi:10.4088/pcc.15r01821. 24 October 2018.