Episode 16: Long-Acting Injectable Antipsychotics

Today’s episode covers the treatment option of long acting injectable antipsychotics, including first generation and second generation options, and also how to appropriately convert a patient from oral antipsychotics to a long-acting injection version. Estimated adherence rate in patients taking oral antipsychotics is about 60%. This can be due to the unpleasant potential side effects from antipsychotics, or due to the patient’s belief that they do not have an illness and do not need the treatment. Additionally, some patients may experience auditory hallucinations telling them that they do not need to take the medication. LAI’s can be an excellent treatment choice for patients who have difficulties with medication compliance.

References

  1. Sadock, Benjamin James. Sadock, Virginia Alcott. Ruiz, Pedro. Kaplan & Sadock’s Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. Philadelphia: Lippincott Williams & Wilkins, 2015. Print.
  2. Lauriello, John MD. Campbell, Austin R PharmD BCPP. “Pharmacotherapy for schizophrenia: Long-acting injectable antipsychotic drugs.” com. 5 July 2017. Web. 5 September 2018.
  3. Guzman, Flavio MD. “Long-Acting Injectable Antipsychotics: A Practical Guide for Prescribers.” Psychopharmacology Institute. 10 February 2018. Web. 5 September 2018.
  4. “Haloperidol: Drug Information.” com. Web. 6 September 2018.
  5. “Fluphenazine: Drug Information.” com. Web. 6 September 2018.
  6. “Aripiprazole (short-acting oral and injectable; and long-acting injectable [Abilify Maintena]): Drug Information.” com. Web. 6 September 2018.
  7. “Aripipraozle lauroxil (long-acting injectable [Aristada]): Drug Information.” com. Web. 6 September 2018.
  8. “Risperidone: Drug Information.” com. Web. 6 September 2018.
  9. “Olanzapine: Drug Information.” com. Web. 6 September 2018.
  10. “Paliperidone: Drug Information.” com. Web. 6 September 2018.
  11. Kennedy, William Klugh PharmD BCPP FASHP. “When and how to use long-acting injectable antipsychotics.” MDEdge Psychiatry. 11 August 2012. Web. 5 September 2018.